Blood Glucose Control Solution: What It Is and How to Use It
By Medical Supply Pros | Published: 2026-10-31
Category: How-to Guides
Learn what blood glucose control solution is, when to run a glucose meter accuracy check, and how to use control solution step by step with your meter.
Quick answer
Blood glucose control solution is a liquid with a known glucose level that you test in place of blood to confirm your meter and strips are working within their labeled range. Use it when you open a new strip vial, suspect inaccurate readings, or drop the meter, and always follow your meter's instructions for the correct control range.
Why control solution is not the same as calibration
Many people call this process blood glucose monitor calibration, but control solution does not adjust or recalibrate the meter. It is a check that tells you whether the meter and strips are performing as expected. If the result falls inside the range printed on your strip vial or meter manual, your system is working. If it falls outside, you may need to repeat the test, check strip storage, or contact the manufacturer.
This distinction matters because a passing control test does not mean your meter is perfectly accurate for every reading. It means the system is functioning within its labeled tolerance. Treat it as a periodic confidence check, not a substitute for your healthcare provider's advice or for following your testing schedule.
When to run a control test
Run a control test when you open a new box or vial of test strips, when you suspect your meter or strips have been damaged by heat or moisture, after a drop or other physical shock, and whenever your blood glucose results seem inconsistent with how you feel. Some meters also prompt a control test at set intervals.
Do not use control solution as a way to verify an individual blood glucose reading. It checks the system, not your blood. If you have symptoms that do not match your meter reading, treat the symptoms and contact a healthcare professional rather than relying on a control test alone.
Choosing the right control solution for your meter
Control solutions are formulated for specific meter systems, and high and low solutions test different parts of the meter's range. Use only the solution made for your meter model. For example, the High-Low Control Solution for Harmony Meter is designed for the Harmony meter, while EVENCARE HI LO Control Solutions for G3 Meter are made for EvenCare G3 meters. Using a different brand's solution can produce meaningless results.
If your meter uses both high and low control solutions, test both when your instructions call for it. A high control test checks performance near the upper end of the measuring range, and a low control test checks the lower end. A single solution does not cover the whole range.
How to use control solution step by step
- Gather your supplies and read the instructions: Collect your meter, the test strips that match the meter, the correct control solution for your meter model, and a clean tissue. Read the control solution package insert and your meter manual for the specific range and testing technique. Common mistake: assuming all control solutions work the same way or that the range is printed on the meter rather than the strip vial. Check that the control solution has not expired and that the strip vial is within its use-by date after opening.
- Prepare the control solution: Remove the control solution cap, wipe the dropper tip with a clean tissue, and discard the first drop if your instructions say to do so. Gently squeeze a drop onto a clean, non-absorbent surface if required by your meter's instructions. Common mistake: touching the dropper tip to the test strip or your skin, which can contaminate the solution. Never add control solution directly from the bottle onto a test strip unless your meter manual specifically allows it.
- Test the control solution like a blood sample: Insert a test strip into the meter and apply the control solution drop to the strip using the same technique you use for blood, following your meter's instructions for control testing mode if it has one. Common mistake: forgetting to mark the reading as a control test, which can mix it up with your blood glucose log. If your meter has a control mode, use it so the result is not stored as a blood glucose reading.
- Compare the result with the control range: Wait for the meter to display the result, then compare it with the control range printed on the test strip vial or in the meter manual. The range is specific to the solution level (high or low) and the strip lot. Common mistake: comparing the control result with your personal blood glucose target range instead of the control range. Write down the result, the date, and the strip lot number so you can track patterns over time.
- Repeat or troubleshoot if the result is outside range: If the result falls outside the printed range, repeat the test with a new strip and fresh control solution drop. If it is still outside range, check that the strips and solution are within date, stored properly, and that you used the correct solution for your meter. Contact the meter manufacturer if the problem continues. Common mistake: continuing to use the meter for blood glucose testing without resolving an out-of-range control result. Do not adjust your insulin or other treatment based on an out-of-range control test; use a backup method and seek advice.
Product facts to know
- High-Low Control Solution for Harmony Meter: High-Low Control Solution for Harmony Meter is designed to confirm meter accuracy with a very small blood sample requirement. A small sample requirement can make the control test easier to perform, especially if you have limited dexterity or want to avoid wasting solution.

High-Low Control Solution for Harmony Meter - EVENCARE HI LO Control Solutions for G3 Meter: EVENCARE HI LO Control Solutions for G3 Meter provide high and low control options for all EvenCare G3 meters and deliver results in as little as 6 seconds. Having both high and low solutions lets you check the meter across its range, and fast results make the process quicker to complete.

EVENCARE HI LO Control Solutions for G3 Meter

